Erectile dysfunction (ED) is a well-known health condition that affects approximately 50% of male patients of 40 to 70 years old. Contemporary lifestyle is quite different from the lifestyle that men used to have in last century and represents an active and vigorous process. Likewise, once it gets mixed with negative impacts on health (e.g. aging, stress, cardiac issues, unhealthy lifestyle), that may lead to Erectile Dysfunction (ED). Fortunately, this health condition is subject to treatment and nowadays there are various treatment solutions, which have already proven its effectiveness and available for public use.
The Most Popular Medications
Fortunately, this sickness type can be cured for most of men without resulting in any serious negative effects to health. Cialis, Viagra, Levitra and others are among the most widely applied ED medications in today’s market and surely can assist in attaining erection during a short period of time without causing any harmful effects to men’s health. For example, PDE5 inhibitors treatment shows its efficiency among most of male patients suffering from ED. However, PDE5 inhibitors are not effective when levels of Nitric Oxide (NO), the main influencer of erection, remain low. Currently there are new pharmacological treatments available for ED: Rho-kinase inhibitors, sGC stimulators/activators, as well as sodium nitrite.
Viagra definitely remains one of the major treatments for most of men, suffering from ED (Erectile Dysfunction). ED may be an outcome of various factors, nevertheless Viagra remains the most efficient solution offered nowadays by the market. Viagra or Sildenafil Citrate is usually prescribed as oral administration treatment and includes a combination of Sildenafil citrate salt. Sildenafil citrate comes in crystalline structure and belongs to selective inhibitors group. Viagra is commonly available in 50mg pills, which should be administered before sexual intercourse takes place. The time period within which Viagra should be taken before sexual act, may fluctuate from 30 minutes up to 4 hours, and basically subject to specific patient conditions as well as the physician, who prescribes the medication. In order to attain the expected results without causing any harmful effects to health, it is highly recommended to purchase generic Viagra from reliable and verified sources.
Cialis is also available under different name (i.e. Tadalafil). It is part of selective inhibitors of PDE5 drugs and treats erectile issues observed among men. Hereby, it is very crucial for everyone who decides to initiate PDE5 inhibitors treatment to completely understand the key mechanisms involved in this drug functionality. Due to the fact that Cialis is allowed for prescription to patients above 18 years old, then it is important to be sure that you have reached this age prior to taking this medication.
The key mechanism involved in Cialis functionality includes relaxation and expansion and of walls inside blood vessels, which results in blood flow enhancement inside cavernous penis body and causes erection. However, it is important to understand that Cialis cannot improve libido or sexual desire or resolve problems with ejaculation. Likewise, sexual arousal is still necessary after Cialis administration, so that erection is attained.
Levitra also comes under alternative name of Vardenafil and represents famous ED cure, that exerts relaxation to muscles located inside the blood vessel walls and improves blood flow to certain zones of male body. Usually, Levitra comes with prescription from healthcare specialist to treat Erectile Dysfunction (ED), that is also referred to as impotence. Levitra is not directly related to erection, but exerts improvement of response to any sort of sexual stimulation. Generic Levitra is able to help in attaining erection after sexual stimulation takes place.
The process of attaining erection includes the combination of neurological, psychological, and vascular aspects, which once combined, result in a physiologic reply to stimulation with the penile vasculature. The expansion of smooth arteriolar muscles allows an increase in blood flow inside the blood vessels of the corpora cavernosum and results in erection. This filling obstructs venous outflow from the penis and maintains the penile erection for anticipated sexual intercourse.
Hereby, Erectile Dysfunction refers to difficulties related to initiation or keeping erection sufficiently strong for sexual act. A number of independent studies have been conducted to confirm the ED presence in approximately 50% of male population around the globe of 40 to 70 years old, affecting up to 150 million men around the globe (with approximately 17% of European men being affected). ED may coexist simultaneously with such health conditions as diabetes mellitus, hypertension, atherosclerosis, obesity and others. Illegal drug use, alcoholism, application of pharmacologic agents (e.g. diuretics, β-blockers, antidepressants) have also been reported to have a serious impact on development of ED.
Main Types and Factors Influencing Erectile Dysfunction
There are major classifications of causes of Erectile Dysfunction, such as neurological, psychological, vascular and hormonal pathologies, as well as various combinations of aforesaid factors.
Psychological factors like depression, stress, deficit of sexual arousal, schizophrenia and others may result in troubles with erection. Besides that, ED may also result from sicknesses that affect libido (e.g. stroke, Alzheimer’s, Parkinson’s, brain trauma etc.), and hereby the perception of arousal itself by the brain. Injuries of the spinal cord may negatively affect neural pathways connecting to the sacral region, which results in prevention or inhibition of the process that lead to erection.
Hormones like prolactin, oxytocin, adrenocorticotropic hormone, and androgens, mostly testosterone, have direct relation to erection functionality. Hypogonadism has a significant impact on Erectile Dysfunction, since based on theory, a certain level of testosterone is required in order to generate erection. Likewise, as part of aging process the natural reduction of testosterone generation causes ED to occur.
Endothelial dysfunction as well as Peripheral arterial disease observed during atherosclerosis, diabetes mellitus, hypertension and coronary disease are also able to become a contributing factor to ED. There are also some studies suggesting that ED represents an early sign of potentially developing cardiovascular diseases. Besides that, inability to obstruct venous outflow from the sinusoidal capillary located in the corpora may lead to ED development. This condition may originate from loss of responses from myogenic venous, deterioration of the tunica albuginea, trauma, or dysfunction of endothelial/smooth muscle situated inside the corpora.
Nitric Oxide and its relation to Erectile Dysfunction
Nitric Oxide is believed to be the major vasoactive neurotransmitter related to erectile response. It gets emitted out of non-adrenergic, noncholinergic (NANC) neurons and endothelium. Likewise, erection is directly related to a neurovascular, NANC mechanism, as well as the central nervous system (CNS). Nitric oxide synthase represents the enzyme accountable for conversion of L-arginine into Nitric Oxide (NO) and L-citrulline.
Suggested Diagnosis Methods
For majority of male patients, a physical examination and detailed medical history is a pre-requisite before Erectile Dysfunction can be diagnosed and a suitable treatment can be recommended. If a patient has got any chronic health conditions or any underlying conditions are suspected, then additional tests or a specialist consultation may be required.
The list of tests that can identify any underlying conditions includes:
- Physical examination
It may include thorough examination of penis as well as testicles and verification of nerves for sensitivity.
- Blood tests
A blood sample may be required to be sent to the laboratory to verify any signs of diabetes, heart disease, low levels of testosterone as well as other health conditions.
- Urine tests
Urine tests (urinalysis) is also useful to determine any signs of diabetes as well as other underlying health conditions.
Ultrasound is generally done by a doctor inside the office and includes a transducer hovered above the blood vessels connecting to the penis. It generates a video image that allows specialist to detect any presence of blood flow issues.
Ultrasound sometimes gets combined with injection of medicines inside the penis in order to cause stimulation of blood flow and cause an erection.
- Psychological examination
Your healthcare specialist may require to ask certain questions to check for presence of depression as well as other possible psychological reasons of Erectile Dysfunction.
In overall, Erectile Dysfunction is a serious health condition that definitely affects the lifestyle of many men nowadays. However, there are effective medications and treatment solutions that demonstrate impressive results and reliability in Erectile Dysfunction treatment. Maintaining a healthy lifestyle is definitely going to help to avoid the ED occurrence. The aforesaid drugs have already earned a reputation of a fit-for-purpose and efficient solution for most of men around the globe. Diversified independent clinical studies and researches have confirmed the efficiency of the abovementioned medications. Nevertheless, it is still crucial to perform medical examinations and have a consultation with healthcare specialist in order to make sure that the treatment method is appropriate for your particular situation.
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