Priligy (dapoxetine) is a potent, selective, and fast-acting serotonin reuptake inhibitor. It also has an effect on the reuptake of norepinephrine and dopamine. Researchers believe that the action of dapoxetine is based mainly on inhibition of neuronal serotonin reuptake, followed by increased serotonin activity at receptors involved in the sympathetic nervous system. This system plays an important role in male ejaculation. After administration, Priligy reaches its peak plasma concentration in about two hours.
Packs
Pharmacological modulation of ejaculation is a relatively new concept that goes far beyond the traditional psychosexual model of premature ejaculation etiopathogenesis. The introduction of serotonin reuptake inhibitors, or SSRIs, changed the clinical approach to treating this disorder. However, many studies concerning PE were designed incorrectly or contained methodological errors, which makes their results less reliable.
When studies of known drugs used for PE were reviewed, meta-analysis showed only 14.4% effectiveness overall, while dapoxetine ranked first among the more reliable and effective medications. Unfortunately, drug therapy still has certain limits. After treatment is stopped, the disorder often returns.
Some authors believe that medications should be taken throughout the whole period of sexual activity. At present, the best results are usually achieved when medication is taken for a limited period, often around 60 days, together with couples sexual therapy. This approach helps the man gain better control over ejaculation and strengthen his confidence in overcoming PE.
The mechanism of action
Priligy stands out as the only approved medication specifically intended for premature ejaculation treatment in men aged 18 to 64. It belongs to the class of fast-acting, short-term selective serotonin reuptake inhibitors. The mechanism of action of dapoxetine involves inhibition of serotonin reuptake at neural synapses, which then enhances dopaminergic and noradrenergic transmission. The medication is usually taken on demand, 1 to 3 hours before sexual activity, and not more than once daily. It is absorbed quickly in the gastrointestinal tract and reaches its highest plasma level approximately 1 hour after intake. The drug is also eliminated rapidly, so it does not accumulate in the body.
The pharmacokinetics of Priligy depend on the dose, but they are not significantly affected by food or alcohol consumption. Priligy is metabolized in the liver, including into desmethyl dapoxetine and dimethyl dapoxetine. Its metabolites are eliminated through the kidneys. The medication is not recommended for patients with liver or kidney damage, or for patients taking drugs that affect cytochrome P450, including ketoconazole and ritonavir. It should also be avoided in patients using other serotonin reuptake inhibitors.
Caution is required in patients with cardiovascular diseases. From a clinical point of view, it is also important that no significant interactions with phosphodiesterase type 5 inhibitors were observed. These pharmacological features distinguish Priligy from other selective serotonin reuptake inhibitors and explain why dapoxetine is used specifically as an on-demand treatment for premature ejaculation.
Indications for use
Priligy is a drug intended for men who struggle with premature ejaculation.
The indications for using Priligy are:
- premature ejaculation in men aged 18 to 64;
- intravaginal ejaculation delay time of less than two minutes;
- chronic or recurrent ejaculation with minimal sexual stimulation;
- personal and interpersonal anxiety caused by premature ejaculation;
- poor control or complete lack of control over ejaculation;
- premature ejaculation during sexual contact within the last six months.
Priligy has proven to be an effective treatment option for premature ejaculation. However, its use may not be recommended for every man facing this condition.
Contraindications to the use of Priligy are:
- hypersensitivity to any of the ingredients of the preparation;
- moderate or severe liver disorders;
- mania, hypomania, severe depression, or bipolar disorder;
- heart problems, including heart failure, atrioventricular block, coronary heart disease, or valvular disease;
- use of other serotonergic preparations.
Dosages
Priligy can be taken with or without food. The initial suggested dose is 30 mg, taken approximately three hours before anticipated sexual activity. Depending on effectiveness and tolerability, the dose may be adjusted to 60 mg. However, it is important to remember that Priligy should not be taken every day on a continuous basis. After taking the medication at least six times, the benefits of continued use should be evaluated against the potential risks of frequent dosing.
Side effects
They are divided according to frequency of occurrence:
- dizziness, headaches, and nausea;
- the use of the drug may cause anxiety, agitation, insomnia, decreased libido, sleepiness, blurred vision, tinnitus, diarrhea, vomiting, excessive sweating, erectile dysfunction, or irritability;
- depressive mood, euphoria, nightmares, teeth grinding, fainting, taste disturbance, increased heart rate, and increased blood pressure may occur uncommonly.
Before taking Priligy, please review the included leaflet for detailed information about indications, contraindications, possible side effects, and dosage. You should also seek advice from your doctor or pharmacist. Misuse of any medication can create serious risks to your health and well-being.
Priligy sum-up
Priligy has been proven effective in the treatment of premature ejaculation, with studies showing its strong safety profile and good tolerability. On average, the drug increases the duration of intercourse by 3 to 4 minutes. Dapoxetine can also be used as an on-demand medication in situations where treatment is needed before sexual activity. Its limited side effects and high effectiveness may make it a more favorable option compared with other PE treatments, which can be less effective or associated with a higher rate of adverse effects.
Psychotherapy can also be used as an alternative method or as supportive treatment for PE. The choice of therapy should be discussed with the patient and, when possible, with the partner. Treatment of sexual dysfunctions is becoming an increasingly common issue not only in the offices of psychologists, psychiatrists, and sexologists, but also in the daily medical practice of internists and cardiologists. To sum up, it should be emphasized that PE treatment with dapoxetine is possible and should be considered by doctors of various specialties who care for patients facing this problem.
Disclaimer
This patient information is provided for educational purposes only. This content should not be understood as a recommendation, instruction, or call to action to purchase, start, change, or use the drug without first receiving proper medical advice from a qualified healthcare professional. All trademarks, company names, product names, and references to possible studies are included for informational purposes only. They are used as legal references and with respect for copyright requirements, professional ethics, and the rights of their respective owners.